Composition:

Mechanism of Action:

Meropenem is a broad-spectrum carbapenem antibiotic. The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding-protein (PBP) targets. Its strongest affinities are toward PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa and PBPs 1, 2, and 4 of Staphylococcus aureus. Meropenem has significant stability to hydrolysis by beta-lactamases of most categories, both penicillinases and cephalosporinases produced by Gram-positive and Gram-negative bacteria.

Indications:

Merojen Injection is indicated for the treatment of the following infections in adults and children above 3 months of age, when caused by susceptible bacteria:

• Pneumonia, including community-acquired pneumonia and nosocomial pneumonia
• Complicated urinary tract infections
• Complicated intra-abdominal infections (complicated appendicitis and peritonitis)
• Intra-and post-partum infections
• Complicated skin and skin structure infections
• Broncho-pulmonary infections in cystic fibrosis
• Acute bacterial meningitis

Merojen Injection has been found to be effective in eliminating concurrent bacteraemia in association with bacterial meningitis.

Merojen Injection may be used in the management of neutropenic patients with fever that is suspected to be due to a bacterial infection

Anti Infectives

• Merojen